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AZMango
SF

San Francisco 49ers @ Carolina Panthers

Any-day matchup, Panthers at home · power ratings as of

CAR
Our pick
SFSan Francisco 49ers
64% to win

A probability, not a promise: a 64% pick loses about 4 times in 10.

AZMango model

No market price for this matchup, so there is nothing to compare against.

Advantages Why the 49ers can win

  1. Panthers are missing regulars: CB Akayleb Evans (out), G Damien Lewis (out), LB Jaelan Phillips (out).
  2. Point differential per game: 49ers rank 3rd (+8.3), Panthers 24th (-2.1).
  3. 49ers running game (3rd in EPA) faces the Panthers defense that ranks 31st against it.
  4. Recent scoring margins: worth about 2.3 points to 49ers in our ratings.
  5. Season-long ratings: over the season, betting lines have rated 49ers about 2.1 points stronger.

Disadvantages Why the 49ers may not

  1. 49ers are missing regulars: WR Mike Evans (out), WR Deebo Samuel Sr. (out).
  2. Upset odds: Panthers win 3,650 of 10,000 simulations (36%). A 64% pick still loses about 4 times in 10.
  3. Travel: 49ers cross 3 time zones for this one.
  4. Home field: Panthers play at home, worth roughly 1 to 2 points in recent seasons.
  5. Range of outcomes: in the worst 10% of simulations, 49ers lose by 13 or more.

The line and our numbers

MarketAZMango
SpreadNo line yetSF -4
Total pointsn/a49.6
Win chanceSF n/a · CAR n/aSF 64% · CAR 36%
Fair moneylineSF -174 · CAR +174

No betting line for this pairing. Odds change all the time, so check a sportsbook before acting on any number here.

10,000 simulated games

  • Typical score: CAR 23, SF 27.
  • 80% of simulations land between SF by 21 and CAR by 13.
See live oddsBetMGM DraftKings FanDuel

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Side by side

SFCAR
6-1Record3-4
28.1 3Points per game25.4 9
19.9 6Points allowed27.6 27
+0.19 2Offense EPA/play+0.02 13
-0.03 12Defense EPA/play allowed+0.05 23
-0.4 21Turnover margin/game+0.0 16
5.7% 21Sacks per dropback4.0% 28

Small numbers are league ranks (1 = best). EPA (expected points added) measures how much each play changes a team's expected score.

Last 5 meetings

DateGameScoreWinnerClosing line
2025-11-242025 Wk 12CAR 9 @ SF 20SFSF -7.5
2022-10-092022 Wk 5SF 37 @ CAR 15SFSF -6
2019-10-272019 Wk 8CAR 13 @ SF 51SFSF -4.5
2017-09-102017 Wk 1CAR 23 @ SF 3CARCAR -4.5
2016-09-182016 Wk 2SF 27 @ CAR 46CARCAR -12

Basis: power ratings only (no betting line yet). 10,000 drive-by-drive simulations, calibrated so our percentages match how often teams actually won in a 2020-2026 backtest. Model version 1. How it works

No betting line exists for a game that isn't scheduled, so this uses our own power ratings (they pick about 65% of winners in the backtest). Flip home and away