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AZMango
SF

San Francisco 49ers @ Arizona Cardinals

Any-day matchup, Cardinals at home · power ratings as of

ARI
Our pick
SFSan Francisco 49ers
76% to win

A probability, not a promise: a 76% pick loses about 2 times in 10.

AZMango model

No market price for this matchup, so there is nothing to compare against.

Advantages Why the 49ers can win

  1. Season-long ratings: over the season, betting lines have rated 49ers about 4.5 points stronger.
  2. Recent scoring margins: worth about 3.9 points to 49ers in our ratings.
  3. 49ers passing game (2nd in EPA) faces the Cardinals defense that ranks 30th against it.
  4. Point differential per game: 49ers rank 3rd (+8.3), Cardinals 30th (-9.4).
  5. Simulation: 49ers win 7,650 of 10,000 simulated games.

Disadvantages Why the 49ers may not

  1. 49ers are missing regulars: WR Mike Evans (out), WR Deebo Samuel Sr. (out).
  2. Home field: Cardinals play at home, worth roughly 1 to 2 points in recent seasons.
  3. Upset odds: Cardinals win 2,350 of 10,000 simulations (24%). A 76% pick still loses about 2 times in 10.
  4. Turnover margin per game: Cardinals rank 13th (+0.3), 49ers 21st (-0.4).
  5. Range of outcomes: in the worst 10% of simulations, 49ers lose by 7 or more.

The line and our numbers

MarketAZMango
SpreadNo line yetSF -7.9
Total pointsn/a50.5
Win chanceSF n/a · ARI n/aSF 76% · ARI 24%
Fair moneylineSF -325 · ARI +325

No betting line for this pairing. Odds change all the time, so check a sportsbook before acting on any number here.

10,000 simulated games

  • Typical score: ARI 21, SF 29.
  • 80% of simulations land between SF by 25 and ARI by 7.
See live oddsBetMGM DraftKings FanDuel

Plain links. We are not paid for them and take no bets.

Side by side

SFARI
6-1Record2-5
28.1 3Points per game20.3 26
19.9 6Points allowed29.7 32
+0.19 2Offense EPA/play-0.04 22
-0.03 12Defense EPA/play allowed+0.10 28
-0.4 21Turnover margin/game+0.3 13
5.7% 21Sacks per dropback6.5% 17

Small numbers are league ranks (1 = best). EPA (expected points added) measures how much each play changes a team's expected score.

Last 5 meetings

DateGameScoreWinnerClosing line
2026-09-272026 Wk 3ARI 30 @ SF 36SFSF -7.5
2025-11-162025 Wk 11SF 41 @ ARI 22SFSF -3.5
2025-09-212025 Wk 3ARI 15 @ SF 16SFSF -1.5
2025-01-052024 Wk 18SF 24 @ ARI 47ARIARI -4.5
2024-10-062024 Wk 5ARI 24 @ SF 23ARISF -7

Basis: power ratings only (no betting line yet). 10,000 drive-by-drive simulations, calibrated so our percentages match how often teams actually won in a 2020-2026 backtest. Model version 1. How it works

No betting line exists for a game that isn't scheduled, so this uses our own power ratings (they pick about 65% of winners in the backtest). Flip home and away