21+ only. Information and entertainment, not betting advice. Gambling problem? Call 1-800-NEXT-STEP (Arizona) or 1-800-GAMBLER.

AZMango
SF

San Francisco 49ers @ Los Angeles Rams

Any-day matchup, Rams at home · power ratings as of

LA
Our pick
LALos Angeles Rams
54% to win

A probability, not a promise: a 54% pick loses about 5 times in 10.

AZMango model

No market price for this matchup, so there is nothing to compare against.

Advantages Why the Rams can win

  1. 49ers are missing regulars: WR Mike Evans (out), WR Deebo Samuel Sr. (out).
  2. Simulation: Rams win 5,350 of 10,000 simulated games.
  3. Season-long ratings: over the season, betting lines have rated Rams about 1.2 points stronger.
  4. Home field: Rams play at home, worth roughly 1 to 2 points in recent seasons.
  5. Strength: Rams rank 5th in defense, EPA per play allowed (-0.06).

Disadvantages Why the Rams may not

  1. Upset odds: 49ers win 4,650 of 10,000 simulations (46%). A 54% pick still loses about 5 times in 10.
  2. 49ers running game (3rd in EPA) faces the Rams defense that ranks 22nd against it.
  3. Point differential per game: 49ers rank 3rd (+8.3), Rams 12th (+1.6).
  4. Recent scoring margins: worth about 1.0 points to 49ers in our ratings.
  5. Explosive plays (20+ yards) per game: 49ers rank 4th (4.0), Rams 17th (3.6).

The line and our numbers

MarketAZMango
SpreadNo line yetLA -1.6
Total pointsn/a50.6
Win chanceSF n/a · LA n/aSF 46% · LA 54%
Fair moneylineSF +115 · LA -115

No betting line for this pairing. Odds change all the time, so check a sportsbook before acting on any number here.

10,000 simulated games

  • Typical score: LA 26, SF 24.
  • 80% of simulations land between SF by 15 and LA by 18.
See live oddsBetMGM DraftKings FanDuel

Plain links. We are not paid for them and take no bets.

Side by side

SFLA
6-1Record3-4
28.1 3Points per game24.3 11
19.9 6Points allowed22.7 16
+0.19 2Offense EPA/play+0.06 10
-0.03 12Defense EPA/play allowed-0.06 5
-0.4 21Turnover margin/game-0.7 29
5.7% 21Sacks per dropback4.2% 27

Small numbers are league ranks (1 = best). EPA (expected points added) measures how much each play changes a team's expected score.

Last 5 meetings

DateGameScoreWinnerClosing line
2026-09-102026 Wk 1SF 27 @ LA 7SFLA -3.5
2025-11-092025 Wk 10LA 42 @ SF 26LALA -5.5
2025-10-022025 Wk 5SF 26 @ LA 23SFLA -8.5
2024-12-122024 Wk 15LA 12 @ SF 6LASF -3
2024-09-222024 Wk 3SF 24 @ LA 27LASF -6

Basis: power ratings only (no betting line yet). 10,000 drive-by-drive simulations, calibrated so our percentages match how often teams actually won in a 2020-2026 backtest. Model version 1. How it works

No betting line exists for a game that isn't scheduled, so this uses our own power ratings (they pick about 65% of winners in the backtest). Flip home and away